Apache2 at 99% cpu: possible attack

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This web hosting review was started by Nokao on 2009-09-14 13:50:56:

Hi …

I found this on my logs:
[Mon Sep 14 10:46:11 2009] [error] [client 88.191.81.198] File does not exist: /var/www/ELAN-singoli/in_costruzione/e-mail
[Mon Sep 14 14:09:07 2009] [error] [client 69.158.249.49] File does not exist: /var/www/ELAN-singoli/in_costruzione/phpmyadmin

And after that the server was blocked at 99% (apache2).

I have this version installed, do someone knows a solution?
Server Version: Apache/2.2.11 (Ubuntu) mod_jk/1.2.26 PHP/5.2.6-3ubuntu4.2
with Suhosin-Patch

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