Disadvantages about remote access

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This web hosting review was started by winter07 on 2009-07-07 01:24:10:

1. I have an application on my home PC to remotely access a database on a remote PC. What is the disadvantages of doing this? Except for the speed drop (is it significant?)
2. I have a website on a remote server (host) to access the database on my own home PC. What is the disadvantages of doing this? Except for speed drop. Like will the connection be not stable, easy to attack?
3. If I am going to host my website and my database in my own PC. I install Windows Server or IIS to host. What is the disadvantage of doing this? Will my PC be exposed to attacks, will the bandwidth be a trouble?

Thanks for suggestions and I hope there can be some concrete examples.

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